The last proposed system of RBC vasodilation within the existence of nitrite is the reduction of nitrite to NO by Hb. Brooks to start with researched the nitrite Hb conversation in 1937 which perform was afterwards extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to kind metHb and NO (Brooks, 1937; D